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MacFarlane, who made his feature directorial debut earlier this year with the hit comedy Ted, will appear in an episode entitled 'Dangers on a Train', which is slated to kick off The Simpsons' 25th season next fall. He will lend his voice to a character named Ben, who sets out to woo Marge after the Simpsons matriarch accidentally stumbles onto a dating site for married people. MacFarlane will also get to flex his vocals with a rendition of Fred Astaire's 'The Way You Look Tonight'.
"We wanted to come together in a bipartisan way to make Fox Sunday night rock," said Simpsons show-runner Al Jean. "We thought we had a great part that he’d be perfect for, and it would be great to have him on our show, so it worked out just right. There’s been a little rivalry. We’re both humor shows and we make jokes, but it’s always been friendly. I’m hopeful that there will be something of us on their show but that’s up to them. We’d certainly welcome it"