The new film centres on a shy farmer, who lose everything, including his girlfriend, after losing his bottle and pulling out of a gunfight. But, his luck changes when he meets the wife of a notoriously ruthless outlaw who offers to teach him how to shoot. However, whilst thinking that this will help save his relationship and win back his girlfriend, the farmer begins to fall head-over-heels for the outlaw's wife, and when the outlaw returns to reclaim his woman, hilarity ensues.
After the $500 million worldwide gross of Ted last summer, MacFarlane’s film credentials are on the rise. He will again direct A Million Ways... with Ted producer Scott Stuber set to produce. No release date has been set, and it's unclear whether this will be MacFarlane’s next project or if he will start work on this after shooting Ted 2.